https://blog.lynxflow.co/en/tags/half-life/Recent content in Half-Life on Lynx Tech BlogHugo -- gohugo.ioenFri, 21 Aug 2026 00:00:00 +0800https://blog.lynxflow.co/en/posts/active-metabolites-once-daily-dosing/Fri, 21 Aug 2026 00:00:00 +0800https://blog.lynxflow.co/en/posts/active-metabolites-once-daily-dosing/<img src="https://blog.lynxflow.co/images/active-metabolites-once-daily-dosing.png" alt="Featured image of post One Pill Lasts All Day? How Active Metabolites Extend Drug Effects" />An Anti-Intuitive Phenomenon Many psychiatric medications are taken only once daily, yet the drugs themselves often have relatively short half-lives. Take bupropion—a norepinephrine-dopamine reuptake inhibitor (NDRI) used for depression, smoking cessation, and ADHD. Its immediate-release formulation has a half-life of approximately 21 hours. By classic pharmacokinetic principles, it should be dosed three times daily (TID) to maintain steady-state concentrations. Yet clinically, bupropion XL (ext